Development of a Roadmap for Action on New Approach Methodologies in Risk Assessment
نویسندگان
چکیده
While whole animal studies have their place in risk assessment of food and feed components, it is thought that more modern approaches such as human focused new approached methodologies (NAMs) would bring advantages including a greater focus to the species, on molecular mechanism kinetics possibility addressing susceptible populations. This report outlines thinking from authors culminates activity proposals seven distinct but interacting scientific areas i.e. development additional AOPs/AOP networks (AOPs), advanced cell culture models Organ chip (OoC), toxicokinetic with physiological based kinetic modelling (PBK), exposome, susceptibility, data integration concepts assessment. Furthermore, Forum proposed facilitate implementation The was compiled by project team, renowned experts various areas, recommendations were discussed EFSA further refined following consultation external via dedicated workshop. are convinced if taken up, there will be significant impact field, resulting increasing uptake utilisation these emerging technologies all stakeholders involved.
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ژورنال
عنوان ژورنال: EFSA supporting publications
سال: 2022
ISSN: ['2397-8325']
DOI: https://doi.org/10.2903/sp.efsa.2022.en-7341